Up-down approach has potential to dramatically accelerate the creation of metal-organic frameworks

https://phys.org/news/2024-09-strategy-advances-discovery-metal-frameworks.html

"customizable structure strategy for designing MOFs... .bottom-up: selecting metal clusters/ organic ligands, followed by exploration of potential structures, top-down: begins with desired structure identifying appropriate components achieve target structure... combined: not constrained by predefined components/ structural restrictions... identified 26 new zirconium-based MOFs, synthesizing 2... ribbon representation visualizes precise geometric features of organic ligands... catalysis, gas storage, environmental remediation"