Discovery of MCLA-158, the first clinical candidate screened in organoids targeting cancer stem cells of solid tumors

https://medicalxpress.com/news/2022-04-discovery-mcla-clinical-candidate-screened.html

"EGFR activity promotes uncontrolled cell growth, LGR5 marks surface of cancer stem cells... development of MCLA-158/ Petosemtamab; also on characterization of its mechanism of action. MCLA-158/ Petosemtamab degrades EGFR protein in cancer stem cells that have LGR5 marker, thereby blocking growth and survival pathways in cells that initiate and spread cancer"

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