Researchers find a new route for regulating blood sugar levels independent of insulin

https://medicalxpress.com/news/2022-01-route-blood-sugar-independent-insulin.html

"Salk scientists have discovered a second molecule, produced in fat tissue, that, like insulin, also potently and rapidly regulates blood glucose. Their finding could lead to the development of new therapies for treating diabetes, and also lays the foundation for promising new avenues in metabolism research"

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" IXA4, activates IRE1/XBP1s for just a few hours at a time... it can in principle be given daily without triggering the deleterious signaling seen with constant IRE1 activation, making it a promising candidate... The team used IXA4 to treat mice that were obese... After just eight weeks, the treated mice had improved glucose metabolism and insulin activity, less fat buildup and inflammation in the liver, and no loss of insulin-producing cells in the pancreas... other compounds that can get into a broader set of cells including fat cells"

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