Two independent approaches toward preventing Alzheimer's disease: One method inhibits a protein, the other utilizes re-purposed drugs in tandem

Two Articles

UTSW scientists eliminate key Alzheimer’s feature in animal model
https://www.utsouthwestern.edu/newsroom/articles/year-2021/alzheimers-feature.html

"abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease... might eventually lead to treatments that prevent the memory-robbing condition in humans"

Has a treatment for Alzheimer's been sitting on pharmacy shelves for decades? Scientists have two possible candidates
https://medicalxpress.com/news/2021-11-treatment-alzheimer-pharmacy-shelves-decades.html

"gemfibrozil and retinoic acid, when used in combination, force astrocytes to reverse their destructiveness, and instead reduce amyloid beta in the brain—improving cognitive function. The findings suggest that, perhaps in the not-too-distant future, these drugs can be repurposed to coax astrocytes into a beneficial role, serving as Aβ clearing machines, eliminating the accumulation of plaques and preventing Alzheimer's from unraveling the brain"

Related:

Scientists Develop Simple Blood Test for Early Detection of Alzheimer’s Disease
https://hkust.edu.hk/news/research-and-innovation/hkust-scientists-develop-simple-blood-test-early-detection-alzheimers "distinguishes AD [Alzheimer’s disease] patients from healthy people with more than 96% accuracy. This system can also differentiate among the early, intermediate, and late stages of AD, and can be used to monitor the progression of the disease over time... discovery was made using the proximity extension assay (PEA)... protein measurement technology, to examine the levels of over 1,000 proteins in the plasma of AD patients" Related: (previous blood test, now obsolete): Detecting Alzheimer’s Gets Easier with a Simple Blood Test https://www.scientificamerican.com/article/detecting-alzheimers-gets-easier-with-a-simple-blood-test/ "Rather than serving as a stand-alone tool, the results are meant to enhance the accuracy of a clinical diagnosis by distinguishing Alzheimer’s dementia from memory loss caused by other conditions [unlike the newer blood test that is a stand-alone tool and 96% accurate at that]... calculated using a proprietary algorithm that incorporates the person’s age with measurements of beta-amyloid and a protein called apolipoprotein E"

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