A new method for creating one of chemistry’s most widely used class of compounds is cheaper, simpler and more environmentally friendly

https://www.global.hokudai.ac.jp/blog/120-year-old-reaction-turned-on-its-head-with-environment-friendly-paste-based-method/

"Grignard reagents are essential ingredient in common method for creating carbon-carbon bonds, building blocks of organic molecules... conventional production method... carried out in toxic organic solvents... researchers sidestepped problems by minimizing the amount of organic solvent used and by employing a mechanochemical technique called ball-milling... one-tenth amount... organic solvent used in conventional methods was added"