A single amino acid change in the tumor suppressor protein phosphatase and tensin homolog (PTEN) promotes healthy longevity in humans

https://news.kaist.ac.kr/newsen/html/news/?mode=V&mng_no=17351

"IIS is one of the evolutionarily conserved aging-modulatory pathways present in life forms ranging from tiny roundworms... an excellent model animal that has been widely used for aging research... to humans. The proper reduction of IIS leads to longevity in animals but often causes defects in multiple health parameters including impaired motility, reproduction, and growth... a specific amino acid change... improves health status while retaining the longevity conferred by reduced IIS"